T Cells and Hypertension: Solved and Unsolved Mysteries Regarding the Female Rat | Zendy

Amrita V. Pai | Zendy; Taylor Maddox | Zendy; Kathryn Sandberg | Zendy

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T Cells and Hypertension: Solved and Unsolved Mysteries Regarding the Female Rat

Author(s) -

Amrita V. Pai,

Taylor Maddox,

Kathryn Sandberg

Publication year - 2018

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00011.2018

Subject(s) - pathophysiology , immune system , physiology , disease , medicine , biology , endocrinology , immunology , bioinformatics

T-cell function in female animal models of hypertension is poorly understood since most research is conducted in males. Our findings in Dahl-salt-sensitive and Dahl salt-resistant rats support prior research showing sex-specific T-cell effects in the pathophysiology of hypertension. Further studies are needed to inform clinical studies in both sexes and to provide clues into immune mechanisms underlying susceptibility and resilience to developing hypertension and associated disease.

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