The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology | Zendy

Edmund R.S. Kunji | Zendy; Martin S. King | Zendy; Jonathan J. Ruprecht | Zendy; Chancievan Thangaratnarajah | Zendy

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The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology

Author(s) -

Edmund R.S. Kunji,

Martin S. King,

Jonathan J. Ruprecht,

Chancievan Thangaratnarajah

Publication year - 2020

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00009.2020

Subject(s) - mitochondrion , cytosol , microbiology and biotechnology , biology , mitochondrial carrier , inner mitochondrial membrane , mitochondrial matrix , transport protein , mechanism (biology) , biochemistry , bacterial outer membrane , gene , enzyme , escherichia coli , philosophy , epistemology

Members of the mitochondrial carrier family (SLC25) transport a variety of compounds across the inner membrane of mitochondria. These transport steps provide building blocks for the cell and link the pathways of the mitochondrial matrix and cytosol. An increasing number of diseases and pathologies has been associated with their dysfunction. In this review, the molecular basis of these diseases is explained based on our current understanding of their transport mechanism.

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