Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells | Zendy

Kenton M. Sanders | Zendy; Yoshihiko Kito | Zendy; Sung Jin Hwang | Zendy; Sean M. Ward | Zendy

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Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells

Author(s) -

Kenton M. Sanders,

Yoshihiko Kito,

Sung Jin Hwang,

Sean M. Ward

Publication year - 2016

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00006.2016

Subject(s) - smooth muscle , function (biology) , interstitial cell of cajal , gastrointestinal function , gastrointestinal tract , microbiology and biotechnology , chemistry , biology , medicine , anatomy , endocrinology

Interstitial cells of mesenchymal origin form gap junctions with smooth muscle cells in visceral smooth muscles and provide important regulatory functions. In gastrointestinal (GI) muscles, there are two distinct classes of interstitial cells, c-Kit + interstitial cells of Cajal and PDGFRα + cells, that regulate motility patterns. Loss of these cells may contribute to symptoms in GI motility disorders.

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