Chloride Channels Take Center Stage in Acute Regulation of Excitability in Skeletal Muscle: Implications for Fatigue | Zendy

Ole Bækgaard Nielsen | Zendy; Frank Vincenzo de Paoli | Zendy; Anders Riisager | Zendy; Thomas Holm Pedersen | Zendy

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Chloride Channels Take Center Stage in Acute Regulation of Excitability in Skeletal Muscle: Implications for Fatigue

Author(s) -

Ole Bækgaard Nielsen,

Frank Vincenzo de Paoli,

Anders Riisager,

Thomas Holm Pedersen

Publication year - 2017

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00006.2015

Subject(s) - muscle fatigue , skeletal muscle , neuroscience , medicine , physical medicine and rehabilitation , biology , anatomy , electromyography

Initiation and propagation of action potentials in muscle fibers is a key element in the transmission of activating motor input from the central nervous system to their contractile apparatus, and maintenance of excitability is therefore paramount for their endurance during work. Here, we review current knowledge about the acute regulation of ClC-1 channels in active muscles and its importance for muscle excitability, function, and fatigue.

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