Open AccessPutting the Squeeze on Airway Epithelia
Author(s) -
JinAh Park,
Jeffrey J. Fredberg,
Jeffrey M. Drazen
Publication year - 2015
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00004.2015
Subject(s) - bronchoconstriction , airway , airway hyperresponsiveness , respiratory epithelium , epithelium , asthma , inflammation , immunology , medicine , biology , microbiology and biotechnology , pathology , anesthesia
Asthma is characterized by chronic inflammation, airway hyperresponsiveness, and progressive airway remodeling. The airway epithelium is known to play a critical role in the initiation and perpetuation of these processes. Here, we review how excessive epithelial stress generated by bronchoconstriction is sufficient to induce airway remodeling, even in the absence of inflammatory cells.
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