cAMP and Mitochondria | Zendy

Federica Valsecchi | Zendy; Lavoisier RamosEspiritu | Zendy; Jochen Buck | Zendy; Lonny R. Levin | Zendy; Giovanni Manfredi | Zendy

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cAMP and Mitochondria

Author(s) -

Federica Valsecchi,

Lavoisier RamosEspiritu,

Jochen Buck,

Lonny R. Levin,

Giovanni Manfredi

Publication year - 2013

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00004.2013

Subject(s) - adenylyl cyclase , mitochondrion , phosphorylation , microbiology and biotechnology , bioenergetics , oxidative phosphorylation , protein kinase a , protein phosphorylation , biology , phosphorylation cascade , adcy10 , biochemistry , chemistry , signal transduction , adcy9

Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.

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