Open AccessWhole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters
Author(s) -
Donald M. Bers,
Yang Xiang,
Manuela Zaccolo
Publication year - 2019
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00002.2019
Subject(s) - epiphenomenon , microbiology and biotechnology , myocyte , cell , chemistry , biology , biophysics , biochemistry , philosophy , epistemology
Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total cellular cAMP and PKA, and provides unique physiological insights.
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