Neurochemical Effects of Theta Burst Stimulation as Assessed by Magnetic Resonance Spectroscopy | Zendy

Charlotte J. Stagg | Zendy; Marzena Wylezinska | Zendy; Paul M. Matthews | Zendy; Heidi JohansenBerg | Zendy; Peter Jezzard | Zendy; John C. Rothwell | Zendy; Sven Bestmann | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Neurochemical Effects of Theta Burst Stimulation as Assessed by Magnetic Resonance Spectroscopy

Author(s) -

Charlotte J. Stagg,

Marzena Wylezinska,

Paul M. Matthews,

Heidi JohansenBerg,

Peter Jezzard,

John C. Rothwell,

Sven Bestmann

Publication year - 2009

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.91060.2008

Subject(s) - ctbs , neurochemical , neuroscience , stimulation , transcranial magnetic stimulation , glutamate receptor , gabaergic , psychology , neurotransmission , glutamine , chemistry , inhibitory postsynaptic potential , primary motor cortex , receptor , biochemistry , amino acid

Continuous theta burst stimulation (cTBS) is a novel transcranial stimulation technique that causes significant inhibition of synaptic transmission for <or=1 h when applied over the primary motor cortex (M1) in humans. Here we use magnetic resonance spectroscopy to define mechanisms mediating this inhibition by noninvasively measuring local changes in the cortical concentrations of gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx). cTBS to the left M1 led to an increase in GABA compared with stimulation at a control site without significant change in Glx. This direct evidence for increased GABAergic interneuronal activity is framed in terms of a new hypothesis regarding mechanisms underlying cTBS.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research