Multiple serotonergic paths to antidepressant efficacy | Zendy

PierreEric Lutz | Zendy

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Multiple serotonergic paths to antidepressant efficacy

Author(s) -

PierreEric Lutz

Publication year - 2013

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.01093.2012

Subject(s) - serotonergic , antidepressant , neuroscience , serotonin , psychology , animal models of depression , fluoxetine , depression (economics) , reuptake inhibitor , serotonin uptake inhibitors , serotonin reuptake inhibitor , medicine , animal studies , pharmacology , receptor , hippocampus , macroeconomics , economics

Depression is a leading cause of disability worldwide. Brain mechanisms underlying the clinical antidepressant efficacy of selective serotonin reuptake inhibitors (SSRI), currently the first-line treatment, remain poorly understood. Recent animal studies have implicated multiple serotonin receptor subtypes in SSRI response, opening new therapeutic perspectives.

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