Neuroinflammation and the cGAS-STING pathway | Zendy

Alfred C. Chin | Zendy

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Neuroinflammation and the cGAS-STING pathway

Author(s) -

Alfred C. Chin

Publication year - 2019

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00848.2018

Subject(s) - neuroinflammation , sting , neuroimmunology , neurodegeneration , stimulator of interferon genes , neuroscience , signal transduction , biology , cytosol , microbiology and biotechnology , immunology , disease , medicine , innate immune system , immune system , inflammation , central nervous system , biochemistry , pathology , enzyme , engineering , aerospace engineering

The recent discovery of cyclic GMP-AMP synthase (cGAS) as the mammalian cytosolic DNA sensor has profound therapeutic implications for infection, immunology, and cancer. Because neurovirology, neuroimmunology, neuro-oncology, and neurodegeneration implicate cytosolic DNA sensing, cGAS activation and induction of the downstream signaling protein stimulator of interferon genes (STING) has become increasingly recognized as a crucial determinant of neuropathophysiology. This Neuro Forum article reviews recent advances on the role of cGAS-STING signaling in neuroinflammation and neurological disease.

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