Accumulation of methylglyoxal increases the advanced glycation end-product levels in DRG and contributes to lumbar disk herniation-induced persistent pain | Zendy

Cuicui Liu | Zendy; Xinsheng Zhang | Zendy; Yuting Ruan | Zendy; Zhuxi Huang | Zendy; Subo Zhang | Zendy; Meng Liu | Zendy; Hai-Jie Luo | Zendy; Shaoling Wu | Zendy; Chao Ma | Zendy

Open Access

Accumulation of methylglyoxal increases the advanced glycation end-product levels in DRG and contributes to lumbar disk herniation-induced persistent pain

Author(s) -

Cuicui Liu,

Xinsheng Zhang,

Yuting Ruan,

Zhuxi Huang,

Subo Zhang,

Meng Liu,

Hai-Jie Luo,

Shaoling Wu,

Chao Ma

Publication year - 2017

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00745.2016

Subject(s) - methylglyoxal , dorsal root ganglion , glycation , medicine , lumbar , advanced glycation end product , neuropathic pain , sciatica , anesthesia , allodynia , hyperalgesia , pharmacology , chemistry , endocrinology , nociception , diabetes mellitus , anatomy , surgery , dorsum , biochemistry , receptor , enzyme

Our study demonstrates that methylglyoxal accumulation via increasing advanced glycation end-product levels in dorsal root ganglion contributes to the persistent pain induced by lumbar disk herniation, which proposed potential targets for the treatment of lumbar disk herniation-induced persistent pain.

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