Is accelerated, high-dose theta burst stimulation a panacea for treatment-resistant depression? | Zendy

Kevin A. Caulfield | Zendy

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Is accelerated, high-dose theta burst stimulation a panacea for treatment-resistant depression?

Author(s) -

Kevin A. Caulfield

Publication year - 2019

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00537.2019

Subject(s) - stimulation , depression (economics) , panacea (medicine) , treatment resistant depression , psychology , extant taxon , brain stimulation , deep brain stimulation , medicine , anesthesia , neuroscience , antidepressant , hippocampus , biology , pathology , alternative medicine , disease , evolutionary biology , parkinson's disease , economics , macroeconomics

A recent study by Williams et al. (Williams NR, Sudheimer KD, Bentzley BS, Pannu J, Stimpson KH, Duvio D, Cherian K, Hawkins J, Scherrer KH, Vyssoki B, DeSouza D, Raj KS, Keller J, Schatzberg AF. Brain 141: e18, 2018) used accelerated, high-dose intermittent theta burst stimulation (iTBS) to treat highly treatment-resistant depression patients. Remarkably, most patients remitted, but the durability of therapeutic response was weak and all patients relapsed within 2 wk posttreatment. This mini-review examines the “fast on, fast off” effects of accelerated, high-dose iTBS for depression and suggests a new treatment that would combine the strengths of multiple extant iTBS protocols.

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