Surge of corticocardiac coupling in SHRSP rats exposed to forebrain cerebral ischemia | Zendy

Fangyun Tian | Zendy; Tiecheng Liu | Zendy; Gang Xu | Zendy; Talha Ghazi | Zendy; Azeem Sajjad | Zendy; Peter Farrehi | Zendy; Michael M. Wang | Zendy; Jimo Borjigin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Surge of corticocardiac coupling in SHRSP rats exposed to forebrain cerebral ischemia

Author(s) -

Fangyun Tian,

Tiecheng Liu,

Gang Xu,

Talha Ghazi,

Azeem Sajjad,

Peter Farrehi,

Michael M. Wang,

Jimo Borjigin

Publication year - 2019

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00533.2018

Subject(s) - forebrain , medicine , cardiology , ischemia , heart rate variability , autonomic nervous system , heart rate , stroke (engine) , sudden death , sudden cardiac death , anesthesia , neuroscience , central nervous system , psychology , blood pressure , mechanical engineering , engineering

Sudden death is an important but underrecognized consequence of stroke. Acute stroke can disturb central control of autonomic function and result in cardiac dysfunction and sudden death. Previous study showed that bilateral common carotid artery ligation (BCCAL) in the spontaneously hypertensive stroke-prone rat strain (SHRSP) is a well-established model for forebrain ischemic sudden death. This study aims to investigate the temporal dynamic changes in electrical activities of the brain and heart and functional interactions between the two vital organs following forebrain ischemia. EEG and ECG signals were simultaneously collected from nine SHRSP and eight Wistar-Kyoto (WKY) rats. RR interval was analyzed to investigate the cardiac response to brain ischemia. EEG power and coherence (CCoh) analysis were conducted to study the cortical response. Corticocardiac coherence (CCCoh) and directional connectivity (CCCon) were analyzed to determine brain-heart connection. Heart rate variability (HRV) was analyzed to evaluate autonomic functionality. BCCAL resulted in 100% mortality in SHRSP within 14 h, whereas no mortality was observed in WKY rats. The functionality of both the brain and the heart were significantly altered in SHRSP compared with WKY rats after BCCAL. SHRSP, but not WKY rats, exhibited intermittent surge of CCCoh, which paralleled the elevated CCCon and reduced HRV, following the onset of ischemia until sudden death. Elevated brain-heart coupling invariably associated with the disruption of the autonomic nervous system and the risk of sudden death. This study may improve our understanding of the mechanism of forebrain ischemia-induced sudden death. NEW & NOTEWORTHY This study demonstrates a marked surge of corticocardiac coupling in rats dying from focal cerebral ischemia, consistent with our earlier data in rats exposed to fatal asphyxia. Since the bidirectional electrical signal coupling (corticocardiac coherence) and communication (corticocardiac connectivity) between the brain and the heart are only identified in dying animals, they could be used as potential biomarkers to predict the risk of sudden death.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research