Isoflurane inhibits a Kir4.1/5.1-like conductance in neonatal rat brainstem astrocytes and recombinant Kir4.1/5.1 channels in a heterologous expression system | Zendy

Mengchan Ou | Zendy; FuShan Kuo | Zendy; Xinnian Chen | Zendy; Uri Kahanovitch | Zendy; Michelle L. Olsen | Zendy; Guizhi Du | Zendy; Daniel K. Mulkey | Zendy

Open Access

Isoflurane inhibits a Kir4.1/5.1-like conductance in neonatal rat brainstem astrocytes and recombinant Kir4.1/5.1 channels in a heterologous expression system

Author(s) -

Mengchan Ou,

FuShan Kuo,

Xinnian Chen,

Uri Kahanovitch,

Michelle L. Olsen,

Guizhi Du,

Daniel K. Mulkey

Publication year - 2020

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00358.2020

Subject(s) - isoflurane , brainstem , astrocyte , respiratory system , gating , neuroscience , anesthesia , chemistry , electrophysiology , pharmacology , medicine , biology , central nervous system

An unwanted side effect of isoflurane anesthesia is suppression of breathing. Despite this clinical significance, effects of isoflurane on cellular and molecular elements of respiratory control are not well understood. Here, we show that isoflurane inhibits heteromeric Kir4.1/5.1 channels in a mammalian expression system, and a Kir4.1/5.1-like conductance in astrocytes in a brainstem respiratory center. These results identify astrocyte Kir4.1/5.1 channels as novel targets of isoflurane and potential substrates for altered respiratory control during isoflurane anesthesia.

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