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The stress response has profound implications on health and behavior and stress is considered a risk factor for the development of psychopathologies including depression. The neural mechanisms supporting successful stress recovery are not fully understood; however, a novel study by Yang et al. (Yang X, Garcia KM, Jung Y, Whitlow CT, McRae K, Waugh CE. Soc Cogn Affect Neurosci 13: 256–268, 2018) demonstrates that ventromedial prefrontal cortex (vmPFC) activation during a stressor is related to improved stress recovery, and that decentering is able to mediate this relationship, suggesting a role during stress recovery. It was also revealed that vmPFC activation at different time points during the stressor predicts altering aspects of stress recovery, an observation that was only possible due to the adoption of change-point analysis.

Decentering mediates the relationship between vmPFC activation during a stressor and positive emotion during stress recovery