PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model | Zendy

Connie MackenzieGray Scott | Zendy; R. Ryley Parrish | Zendy; Darren Walsh | Zendy; Claudia Racca | Zendy; Rita M. Cowell | Zendy; Andrew J. Trevelyan | Zendy

Open Access

PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model

Author(s) -

Connie MackenzieGray Scott,

R. Ryley Parrish,

Darren Walsh,

Claudia Racca,

Rita M. Cowell,

Andrew J. Trevelyan

Publication year - 2021

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00295.2021

Subject(s) - parvalbumin , neuroscience , coactivator , gabaergic , interneuron , depolarization , chemistry , biology , inhibitory postsynaptic potential , transcription factor , endocrinology , gene , biochemistry

Parvalbumin expressing interneurons are considered to play an important role in regulating cortical activity. We were surprised, therefore, to find that knocking down the transcriptional coactivator, PGC-1α, specifically in this class of interneurons appears to slow ictogenesis. This anti-ictogenic effect is associated with reduced activity in preictal discharges, but with a far longer period of these discharges before the first seizure-like events finally start. Thus, PGC-1α knockdown may promote schizophrenia while reducing epileptic tendencies.

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