Open AccessPV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model
Author(s) -
Connie A. Mackenzie-Gray Scott,
R. Ryley Parrish,
Darren Walsh,
Claudia Racca,
Rita M. Cowell,
Andrew J. Treveylan
Publication year - 2022
Publication title -
journal of neurophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.302
H-Index - 245
eISSN - 1522-1598
pISSN - 0022-3077
DOI - 10.1152/jn.00295.2021
Subject(s) - parvalbumin , neuroscience , coactivator , gabaergic , interneuron , depolarization , chemistry , biology , inhibitory postsynaptic potential , transcription factor , endocrinology , gene , biochemistry
Parvalbumin expressing interneurons are considered to play an important role in regulating cortical activity. We were surprised, therefore, to find that knocking down the transcriptional coactivator, PGC-1α, specifically in this class of interneurons appears to slow ictogenesis. This anti-ictogenic effect is associated with reduced activity in preictal discharges, but with a far longer period of these discharges before the first seizure-like events finally start. Thus, PGC-1α knockdown may promote schizophrenia while reducing epileptic tendencies.