Fibrinogen-cellular prion protein complex formation on astrocytes | Zendy

Mariam Charkviani | Zendy; Nino Muradashvili | Zendy; Nurul Sulimai | Zendy; David Lominadze | Zendy

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Fibrinogen-cellular prion protein complex formation on astrocytes

Author(s) -

Mariam Charkviani,

Nino Muradashvili,

Nurul Sulimai,

David Lominadze

Publication year - 2020

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00224.2020

Subject(s) - astrocyte , glial fibrillary acidic protein , immunoprecipitation , tropomyosin receptor kinase b , microbiology and biotechnology , western blot , receptor , biology , neuroglia , chemistry , neurotrophic factors , immunohistochemistry , endocrinology , immunology , biochemistry , antibody , central nervous system , gene

For the first time we showed that fibrinogen (Fg) can associate with cellular prion protein (PrP C ) on the surface of cultured mouse brain astrocytes. At high levels, Fg causes upregulation of astrocyte PrP C and astrocyte activation accompanied with overexpression of tyrosine receptor kinase B (TrkB), which results in nitric oxide (NO) production and generation of reactive oxygen species (ROS). Fg/PrP C interaction can be a triggering mechanism for TrkB-NO-ROS axis activation and the resultant astrocyte-mediated neurodegeneration.

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