Validation of electrical stimulation models: intracellular calcium measurement in three-dimensional scaffolds | Zendy

Robert D. Adams | Zendy; Brinda Gupta | Zendy; Amy B. Harkins | Zendy

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Validation of electrical stimulation models: intracellular calcium measurement in three-dimensional scaffolds

Author(s) -

Robert D. Adams,

Brinda Gupta,

Amy B. Harkins

Publication year - 2017

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00223.2017

Subject(s) - stimulation , neuroscience , calcium , calcium in biology , computer science , biological system , chemistry , psychology , biology , organic chemistry

Electrical stimulation is used to enhance neuron growth, and the role of neuronal intracellular calcium concentration ([Ca 2+ ] i ) is an area of research interest. Widely varying stimulation parameters in the literature make it difficult to compare stimulation protocols. The results in this manuscript are the first to show neuronal [Ca 2+ ] i in response to a broad and defined range of electrical pulse durations and intensities. These results validate our previously published novel computational model of [Ca 2+ ] i .

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