Location matters: somatic and dendritic SK channels answer to distinct calcium signals | Zendy

Stephanie Rudolph | Zendy; Monica Thanawala | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Location matters: somatic and dendritic SK channels answer to distinct calcium signals

Author(s) -

Stephanie Rudolph,

Monica Thanawala

Publication year - 2014

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00181.2014

Subject(s) - neuroscience , somatic cell , communication , psychology , biology , genetics , gene

Voltage-dependent calcium channels (VDCCs) couple neuronal activity to diverse intracellular signals with exquisite spatiotemporal specificity. Using calcium imaging and electrophysiology, Jones and Stuart (J Neurosci 33: 19396-19405, 2013) examined the intimate relationship between distinct types of VDCCs and small-conductance calcium-activated potassium (SK) channels that contribute to the compartmentalized control of excitability in the soma and dendrites of cortical pyramidal neurons. Here we discuss the importance of calcium domains for signal specificity, explore the possible functions and mechanisms for local control of SK channels, and highlight technical considerations for the optical detection of calcium signals.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research