Frequency-separated principal component analysis of cortical population activity

A method termed frequency-separated principal component analysis (FS-PCA) is introduced for analyzing populations of simultaneously recorded neurons. This framework extends standard principal component analysis by extracting components of activity delimited to specific frequency bands. FS-PCA revealed that circuits of the primary visual cortex generate a broad range of components dominated by low-frequency activity. Furthermore, low-dimensional fluctuations in population activity modulated the response of individual neurons to sensory input.