TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats | Zendy

Steve McGaraughty | Zendy; Katharine L. Chu | Zendy; Jun Xu | Zendy; Laura Leys | Zendy; Richard J. Radek | Zendy; Michael J. Dart | Zendy; Arthur Gomtsyan | Zendy; Robert George Schmidt | Zendy; Philip R. Kym | Zendy; JillDesiree Brederson | Zendy

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TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats

Author(s) -

Steve McGaraughty,

Katharine L. Chu,

Jun Xu,

Laura Leys,

Richard J. Radek,

Michael J. Dart,

Arthur Gomtsyan,

Robert George Schmidt,

Philip R. Kym,

JillDesiree Brederson

Publication year - 2017

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00104.2017

Subject(s) - nociception , neuroscience , neuropathic pain , antagonist , allodynia , spinal trigeminal nucleus , nociceptor , electrophysiology , transient receptor potential channel , medicine , hyperalgesia , pharmacology , chemistry , receptor , psychology

Recent studies have linked TRPV3 to pain modulation, and much of this work has focused on its role in the skin-primary afferent interface. In this electrophysiological study, we demonstrate that receptor antagonists modulate evoked signals through peripheral mechanisms but blockade of supraspinal TRPV3 receptors contributes to dampening both evoked and nonevoked “pain” through descending modulation. Thus, the full therapeutic potential of TRPV3 antagonists may only be realized with the ability to access receptors in the brain.

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