Phencyclidine administration during neurodevelopment alters network activity in prefrontal cortex and hippocampus in adult rats | Zendy

Celia Kjærby | Zendy; Nanna Hovelsø | Zendy; Nils Ole Dalby | Zendy; Florence Sotty | Zendy

Open Access

Phencyclidine administration during neurodevelopment alters network activity in prefrontal cortex and hippocampus in adult rats

Author(s) -

Celia Kjærby,

Nanna Hovelsø,

Nils Ole Dalby,

Florence Sotty

Publication year - 2017

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00081.2017

Subject(s) - phencyclidine , prefrontal cortex , hippocampus , neuroscience , psychology , electrophysiology , medicine , cognition , nmda receptor , receptor

We show that insults with a NMDA receptor antagonist during neurodevelopment lead to suppressed evoked theta oscillations in ventral hippocampus in adult rats, while evoked gamma oscillations are enhanced and hypersensitive to an acute challenge with a NMDA receptor antagonist in prefrontal cortex. These observations reveal the significance of neurodevelopmental disturbances in the evolvement of schizophrenia-like symptoms and contribute to the understanding of the functional deficits underlying aberrant behavior in this disease.

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