Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia | Zendy

Yingjie Peng | Zendy; Anna Gridina | Zendy; Benjamin Wang | Zendy; Jayasri Nanduri | Zendy; Aaron P. Fox | Zendy; Nanduri R. Prabhakar | Zendy

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Olfactory receptor 78 participates in carotid body response to a wide range of low O₂ levels but not severe hypoxia

Author(s) -

Yingjie Peng,

Anna Gridina,

Benjamin Wang,

Jayasri Nanduri,

Aaron P. Fox,

Nanduri R. Prabhakar

Publication year - 2020

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00075.2020

Subject(s) - carotid body , hypoxia (environmental) , neuroscience , receptor , chemistry , medicine , psychology , communication , electrophysiology , oxygen , organic chemistry

The current study demonstrates that olfactory receptor 78 (Olfr78), a G protein-coupled receptor, is an integral component of the hypoxic sensing mechanism of the carotid body to a wide range of low oxygen levels, but not severe hypoxia, and that Olfr78 participation does not require either lactate or any other short-chain fatty acids, proposed ligands of Olfr78.

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