Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli | Zendy

Michael G. Thor | Zendy; Gareth Morris | Zendy

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Contrasting roles of I_h and the persistent sodium current at subthreshold voltages during naturalistic stimuli

Author(s) -

Michael G. Thor,

Gareth Morris

Publication year - 2016

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00031.2016

Subject(s) - subthreshold conduction , neuroscience , hippocampal formation , sodium channel , tetrodotoxin , chemistry , hippocampus , context (archaeology) , hyperpolarization (physics) , nap , current (fluid) , biophysics , sodium , psychology , biology , physics , voltage , stereochemistry , paleontology , organic chemistry , transistor , quantum mechanics , nuclear magnetic resonance spectroscopy , thermodynamics

The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current ( I NaP ) and the h-current ( I h ), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean ( J Neurophysiol 114: 2376–2389, 2015) used pharmacological methods to discern the roles of I h and I NaP at subthreshold voltages during naturalistic stimuli. We discuss these findings in the context of dorsoventral heterogeneity in the hippocampus and suggest further applications of the method.

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