Open AccessMechanistic insights into how advanced age moves the site of V̇o 2 kinetics limitation upstream
Author(s) -
David C. Poole,
Timothy I. Musch
Publication year - 2009
Publication title -
journal of applied physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.253
H-Index - 229
eISSN - 8750-7587
pISSN - 1522-1601
DOI - 10.1152/japplphysiol.01237.2009
Subject(s) - kinetics , upstream (networking) , upstream and downstream (dna) , chemistry , computer science , physics , telecommunications , quantum mechanics
beyond maturity, exercise tolerance declines inexorably with advancing age. Central to resolving the mechanistic bases for this phenomenon is understanding the effects of aging on the O2 transport system. This contention is based on the established and systematic age-related reduction in the maximal
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