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A registration-based multiscale method to obtain a deforming geometric model of mouse acinus is presented. An intact mouse lung was fixed by means of vascular perfusion at a hydrostatic inflation pressure of 20 cmH(2)O. Microcomputed tomography (μCT) scans were obtained at multiple resolutions. Substructural morphometric analysis of a complete acinus was performed by computing a surface-to-volume (S/V) ratio directly from the 3D reconstruction of the acinar geometry. A geometric similarity is observed to exist in the acinus where S/V is approximately preserved anywhere in the model. Using multiscale registration, the shape of the acinus at an elevated inflation pressure of 25 cmH(2)O is estimated. Changes in the alveolar geometry suggest that the deformation within the acinus is not isotropic. In particular, the expansion of the acinus (from 20 to 25 cmH(2)O) is accompanied by an increase in both surface area and volume in such a way that the S/V ratio is not significantly altered. The developed method forms a useful tool in registration-driven fluid and solid mechanics studies as displacement of the alveolar wall becomes available in a discrete sense.

Multiscale imaging and registration-driven model for pulmonary acinar mechanics in the mouse