Airway smooth muscle in the pathophysiology and treatment of asthma | Zendy

Diana Doeing | Zendy; Julian Solway | Zendy

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Airway smooth muscle in the pathophysiology and treatment of asthma

Author(s) -

Diana Doeing,

Julian Solway

Publication year - 2013

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00950.2012

Subject(s) - bronchoconstriction , pathophysiology , medicine , pathophysiology of asthma , asthma , airway , airway hyperresponsiveness , inflammation , respiratory system , cardiology , immunology , anesthesia

Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is responsible for acute bronchoconstriction, which is potentiated by constrictor hyperresponsiveness, impaired relaxation and length adaptation. ASM also contributes to airway remodeling and inflammation in asthma. In light of this, ASM is an important target in the treatment of asthma.

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