Limitations to exercise tolerance in type 1 diabetes: the role of pulmonary oxygen uptake kinetics and priming exercise | Zendy

Richie P. Goulding | Zendy; Denise M. Roche | Zendy; Sam N. Scott | Zendy; Shunsaku Koga | Zendy; Philip J. Weston | Zendy; Simon Marwood | Zendy

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Limitations to exercise tolerance in type 1 diabetes: the role of pulmonary oxygen uptake kinetics and priming exercise

Author(s) -

Richie P. Goulding,

Denise M. Roche,

Sam N. Scott,

Shunsaku Koga,

Philip J. Weston,

Simon Marwood

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00892.2019

Subject(s) - kinetics , deoxygenation , medicine , priming (agriculture) , diabetes mellitus , type 2 diabetes , physical exercise , type 1 diabetes , ventilatory threshold , chemistry , vo2 max , endocrinology , biochemistry , biology , heart rate , physics , germination , botany , quantum mechanics , blood pressure , catalysis

Patients with type 1 diabetes demonstrated slower oxygen uptake (V̇o 2 ) kinetics compared with healthy control subjects. Furthermore, a prior bout of high-intensity exercise speeded V̇o 2 kinetics and increased critical power in people with type 1 diabetes. Prior exercise speeded muscle deoxygenation kinetics, indicating that V̇o 2 kinetics in type 1 diabetes are limited primarily by oxygen extraction and/or intracellular factors. These findings highlight the potential for interventions that decrease metabolic inertia for enhancing exercise tolerance in this condition.

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