Hydraulic force is a novel mechanism of diastolic function that may contribute to decreased diastolic filling in HFpEF and facilitate filling in HFrEF | Zendy

Katarina StedingEhrenborg | Zendy; Erik Hedström | Zendy; Marcus Carlsson | Zendy; Elira Maksuti | Zendy; Michael Broomé | Zendy; Martin Ugander | Zendy; Martin Magnusson | Zendy; J. G. Smith | Zendy; Håkan Arheden | Zendy

Open Access

Hydraulic force is a novel mechanism of diastolic function that may contribute to decreased diastolic filling in HFpEF and facilitate filling in HFrEF

Author(s) -

Katarina StedingEhrenborg,

Erik Hedström,

Marcus Carlsson,

Elira Maksuti,

Michael Broomé,

Martin Ugander,

Martin Magnusson,

J. G. Smith,

Håkan Arheden

Publication year - 2021

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00890.2020

Subject(s) - diastole , cardiology , heart failure with preserved ejection fraction , medicine , heart failure , ejection fraction , diastolic function , mechanism (biology) , diastolic heart failure , cardiac function curve , blood pressure , philosophy , epistemology

It is a previously unrecognized physiological mechanism of the heart that diastolic filling occurs with the help of hydraulics. In patients with heart failure with preserved ejection fraction, atrial dilatation may cause the net hydraulic force to work against cardiac filling, thus further augmenting diastolic dysfunction. In contrast, it may work favorably in patients with dilated ventricles, as in heart failure with reduced ejection fraction.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research