Hypoglossal nerve stimulation in a rabbit model of obstructive sleep apnea reduces apneas and improves oxygenation | Zendy

Matthew A. Schiefer | Zendy; J. E. Gamble | Zendy; Jonathan Z. Baskin | Zendy; Kingman P. Strohl | Zendy

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Hypoglossal nerve stimulation in a rabbit model of obstructive sleep apnea reduces apneas and improves oxygenation

Author(s) -

Matthew A. Schiefer,

J. E. Gamble,

Jonathan Z. Baskin,

Kingman P. Strohl

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00828.2019

Subject(s) - hypoglossal nerve , neurostimulation , obstructive sleep apnea , medicine , oxygenation , stimulation , anesthesia , genioglossus , apnea , sleep (system call) , sleep apnea , breathing , tongue , pathology , computer science , operating system

This report describes a rabbit model for testing the impact of hypoglossal nerve stimulation (HNS) on obstructive apneas. Obstructive sleep apnea (OSA) is induced by injecting hyaluronic acid (as a filler) into the base of the tongue. HNS reduced the length and rate of obstructions and improved oxygenation during sleep. Our efforts with this model advanced understanding of the complexities of this OSA preclinical model for neurostimulation reversal of sleep-disordered breathing.

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