Increased sympathetic responses induced by chronic obstructive sleep apnea are caused by sleep fragmentation | Zendy

Caroline B. Ferreira | Zendy; G.H.M. Schoorlemmer | Zendy; Antonio A. Rocha | Zendy; Sérgio L. Cravo | Zendy

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Increased sympathetic responses induced by chronic obstructive sleep apnea are caused by sleep fragmentation

Author(s) -

Caroline B. Ferreira,

G.H.M. Schoorlemmer,

Antonio A. Rocha,

Sérgio L. Cravo

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00811.2019

Subject(s) - obstructive sleep apnea , sleep apnea , hypoxia (environmental) , apnea , medicine , sleep (system call) , chemoreceptor , intermittent hypoxia , stimulation , fragmentation (computing) , anesthesia , endocrinology , biology , chemistry , receptor , organic chemistry , oxygen , computer science , operating system , ecology

Obstructive sleep apnea causes a hyperactive chemoreflex, with increased sympathetic activation. However, it is not clear whether this pathophysiologic mechanism is due to repeated hypoxia or to sleep disruption. The present study suggests that sleep fragmentation contributes importantly to increased sympathetic activation after chemoreceptor stimulation. This suggests that sleep fragmentation has an important role in the sympathetic activation seen in sleep apnea patients.

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