Open AccessThe combination of smoking with vitamin D deficiency impairs skeletal muscle fiber hypertrophy in response to overload in mice
Author(s) -
Tom Tanjeko Ajimé,
Jef Serré,
Rob C I Wüst,
Jatin G. Burniston,
Karen Maes,
Wim Janssens,
Thierry Troosters,
Ghislaine GayanRamirez,
Hans Degens
Publication year - 2021
Publication title -
journal of applied physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.253
H-Index - 229
eISSN - 8750-7587
pISSN - 1522-1601
DOI - 10.1152/japplphysiol.00733.2020
Subject(s) - plantaris muscle , muscle hypertrophy , medicine , endocrinology , denervation , skeletal muscle , pressure overload , soleus muscle , cardiac hypertrophy
Plantaris hypertrophy caused by compensatory overload after denervation of the soleus and gastrocnemius muscles showed increased mass and fiber dimensions, but to a lesser extent when vitamin D deficiency was combined with cigarette smoking. Fatigue resistance was elevated in hypertrophied plantaris, irrespective of diet or smoking, whereas physical fitness, hypertrophic markers, and in situ plantaris force were similar. These data showed that the hypertrophic response to overload is attenuated when both conditions are combined.