Chronic hypercapnia alters lung matrix composition in mouse pups | Zendy

Julie Ryu | Zendy; Gregory P. Heldt | Zendy; Mary Ann Nguyen | Zendy; Orit Gavrialov | Zendy; Gabriel G. Haddad | Zendy

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Chronic hypercapnia alters lung matrix composition in mouse pups

Author(s) -

Julie Ryu,

Gregory P. Heldt,

Mary Ann Nguyen,

Orit Gavrialov,

Gabriel G. Haddad

Publication year - 2010

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00610.2009

Subject(s) - hypercapnia , lung , elastin , endocrinology , respiratory system , medicine , interstitial collagenase , matrix metalloproteinase , fibronectin , extracellular matrix , lung volumes , collagenase , pathology , andrology , chemistry , biology , biochemistry , enzyme

permissive hypercapnia, a stretch-limiting ventilation strategy, often results in high Pa(CO(2)). This strategy is associated with reduced morbidity and mortality in premature infants and its benefits have been attributed to diminished barotrauma. However, little is known about the independent effect of high CO(2) levels during the lung development.

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