The effect of long-term ultra-endurance exercise and SOD2 genotype on telomere shortening with age | Zendy

Bárbara Hernando | Zendy; Marta GilBarrachina | Zendy; Elena Tomás Bort | Zendy; Ignacio MartínezNavarro | Zendy; Eladio ColladoBoira | Zendy; Carlos Hernando Domingo | Zendy

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The effect of long-term ultra-endurance exercise and SOD2 genotype on telomere shortening with age

Author(s) -

Bárbara Hernando,

Marta GilBarrachina,

Elena Tomás Bort,

Ignacio MartínezNavarro,

Eladio ColladoBoira,

Carlos Hernando Domingo

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00570.2020

Subject(s) - telomere , endurance training , sod2 , medicine , healthy aging , gerontology , physical therapy , biology , genetics , oxidative stress , dna , superoxide dismutase

Habitual ultra-endurance exercise seems to promote telomere length maintenance, especially at older ages. In addition, the beneficial effect of ultra-endurance training on biological aging is higher in ultra-trail runners who have been engaged to ultra-endurance training during many years. Finally, and for the first time, this study shows that the SOD2 rs4880 polymorphism has a significant impact on telomere length, as well as on acute inflammatory response to a 107-km trail race.

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