The preponderance of initial orthostatic hypotension in postural tachycardia syndrome | Zendy

Julian M. Stewart | Zendy; Archana Kota | Zendy; Mary Breige O’Donnell-Smith | Zendy; Paul Visintainer | Zendy; Courtney Terilli | Zendy; Marvin S. Medow | Zendy

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The preponderance of initial orthostatic hypotension in postural tachycardia syndrome

Author(s) -

Julian M. Stewart,

Archana Kota,

Mary Breige O’Donnell-Smith,

Paul Visintainer,

Courtney Terilli,

Marvin S. Medow

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00540.2020

Subject(s) - lightheadedness , orthostatic vital signs , medicine , baroreflex , heart rate , tachycardia , cardiorespiratory fitness , anesthesia , blood pressure , postural orthostatic tachycardia syndrome , cardiology , orthostatic intolerance , bradycardia , cerebral blood flow

Significant initial orthostatic hypotension (IOH) occurs in ~50% of postural tachycardia syndrome (POTS) patients and 13% of controls. Heart rate and blood pressure recovery are prolonged in IOH sustaining lightheadedness; IOH is more prevalent and severe in POTS. Altered cerebral blood flow and cardiorespiratory regulation are more prevalent in POTS. Altered heart rate variability and baroreflex gain may cause nearly instantaneous lightheadedness in POTS. IOH alone fails to confer a strong probability of POTS.

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