A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca2+ release capacity in the skeletal muscle of aged mice | Zendy

Hiroaki Eshima | Zendy; Yoshifumi Tamura | Zendy; Saori Kakehi | Zendy; Ryo Kakigi | Zendy; Ryota Hashimoto | Zendy; Katsuhiko Funai | Zendy; Ryuzo Kawamori | Zendy; Hirotaka Watada | Zendy

Open Access

A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca²⁺ release capacity in the skeletal muscle of aged mice

Author(s) -

Hiroaki Eshima,

Yoshifumi Tamura,

Saori Kakehi,

Ryo Kakigi,

Ryota Hashimoto,

Katsuhiko Funai,

Ryuzo Kawamori,

Hirotaka Watada

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00530.2019

Subject(s) - medicine , endocrinology , skeletal muscle , intracellular , chemistry , biology , biochemistry

The aim of this study was to examine the effect of high-fat diet (HFD)-induced obesity on contractile function and Ca 2+ release capacity in aged skeletal muscle. Not only were the force production and peak Ca 2+ levels decreased by aging and HFD feeding, respectively, but also, these interventions had an additive effect in aged HFD-fed mice. These data suggest that the impairment in the contractile force in aged muscle is aggravated by a HFD, which may be due to synergistic dysfunction in intracellular Ca 2+ release.

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