A methodology to explore ventilatory chemosensitivity and opioid-induced respiratory depression risk | Zendy

Tiffany W. Dong | Zendy; David B. MacLeod | Zendy; Antoinette Santoro | Zendy; Zachary Augustine | Zendy; Stratton Barth | Zendy; Mary Cooter | Zendy; Richard E. Moon | Zendy

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A methodology to explore ventilatory chemosensitivity and opioid-induced respiratory depression risk

Author(s) -

Tiffany W. Dong,

David B. MacLeod,

Antoinette Santoro,

Zachary Augustine,

Stratton Barth,

Mary Cooter,

Richard E. Moon

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00460.2020

Subject(s) - remifentanil , depression (economics) , medicine , respiratory system , anesthesia , opioid , receptor , economics , propofol , macroeconomics

Our new and noteworthy methodology allows for exploration of preoperative ventilatory chemosensitivity, measured as the hypercapnic ventilatory response (HCVR), as a risk factor for postoperative opioid-induced respiratory depression (OIRD). This feasible and reliable methodology produced preliminary data that showed highly variable depression of HCVR by remifentanil, predominance of OIRD during light sleep, and potentially negative correlation between OIRD frequency generally and HCVR measurements when measured in the presence of remifentanil. Although the results are preliminary in nature, this novel methodology may guide future studies that can one day lead to effective clinical screening tools.

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