Intermittent hypoxia enhances shear-mediated dilation of the internal carotid artery in young adults | Zendy

Erika Iwamoto | Zendy; Brady E. Hanson | Zendy; Joshua M. Bock | Zendy; Darren P. Casey | Zendy

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Intermittent hypoxia enhances shear-mediated dilation of the internal carotid artery in young adults

Author(s) -

Erika Iwamoto,

Brady E. Hanson,

Joshua M. Bock,

Darren P. Casey

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00274.2020

Subject(s) - internal carotid artery , hypoxia (environmental) , cardiology , medicine , carotid arteries , middle cerebral artery , cerebral circulation , cerebral blood flow , intermittent hypoxia , anesthesia , ischemia , chemistry , oxygen , organic chemistry , obstructive sleep apnea

We explored the effects of cyclic intermittent hypoxia (IH) on shear-mediated dilation of the internal carotid artery (ICA), a potential index of cerebral endothelial function, in young adults. Cyclic IH increased blood flow and shear rate in the ICA and, as a result, increased shear-mediated dilation of the ICA. These data suggest that cyclic IH could potentially be applied as a nonpharmacological therapy to optimize cerebral vascular health.

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