Anatomical variability in the upper tracheobronchial tree: sex-based differences and implications for personalized inhalation therapies | Zendy

Simoni Christou | Zendy; Thanasis Chatziathanasiou | Zendy; Stelios Angeli | Zendy; Pantelis Koullapis | Zendy; Fotos Stylianou | Zendy; Josué Sznitman | Zendy; H. Henry Guo | Zendy; Stavros C. Kassinos | Zendy

Open Access

Anatomical variability in the upper tracheobronchial tree: sex-based differences and implications for personalized inhalation therapies

Author(s) -

Simoni Christou,

Thanasis Chatziathanasiou,

Stelios Angeli,

Pantelis Koullapis,

Fotos Stylianou,

Josué Sznitman,

H. Henry Guo,

Stavros C. Kassinos

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00144.2020

Subject(s) - airway , lumen (anatomy) , lung , medicine , inhalation , sex characteristics , lung volumes , branching (polymer chemistry) , anatomy , physiology , anesthesia , chemistry , organic chemistry

We found significant sex-based morphometric differences in the central airways of healthy men and women that were only mildly attenuated in subsets matched for lung volume. Lumen areas were significantly larger in men (∼30%–50%). Large variability (∼75%–87%) in airway bifurcation angles (60°–122°) was found irrespective of sex. The branching pattern of the right main and right upper bronchi in women (but not in men) follows two phenotypes modulated by lung volume.

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