The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease | Zendy

Scott K. Ferguson | Zendy; Katherine Redinius | Zendy; Julie W. Harral | Zendy; David I. Pak | Zendy; Delaney Swindle | Zendy; Daniel M. Hirai | Zendy; Jamie R. Blackwell | Zendy; Andrew M. Jones | Zendy; Kurt R. Stenmark | Zendy; Paul W. Buehler | Zendy; David Irwin | Zendy

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The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease

Author(s) -

Scott K. Ferguson,

Katherine Redinius,

Julie W. Harral,

David I. Pak,

Delaney Swindle,

Daniel M. Hirai,

Jamie R. Blackwell,

Andrew M. Jones,

Kurt R. Stenmark,

Paul W. Buehler,

David Irwin

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00122.2020

Subject(s) - disease , medicine , dietary nitrate , sickle cell anemia , cell , endocrinology , nitrate , treadmill , anemia , physiology , biology , nitrite , biochemistry , ecology

Sickle cell disease compromises muscle O 2 delivery resulting in exercise intolerance. Dietary nitrate supplementation increases skeletal muscle blood flow during exercise and may improve exercise capacity in a mouse model of sickle cell disease. We investigated the effects of dietary nitrate supplementation on exercise tolerance in a mouse model of sickle cell disease using the treadmill speed-duration relationship (critical speed). Mice with sickle cell disease provided with a dietary nitrate supplement had a critical speed not significantly different from healthy wild-type mice.

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