Ventilation heterogeneity in smokers: role of unequal lung expansion and peripheral lung structure | Zendy

Sylvia Verbanck | Zendy; Mathias Polfliet | Zendy; Daniël Schuermans | Zendy; Bart Ilsen | Zendy; Johan De Mey | Zendy; Eef Vanderhelst | Zendy; Jef Vandemeulebroucke | Zendy

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Ventilation heterogeneity in smokers: role of unequal lung expansion and peripheral lung structure

Author(s) -

Sylvia Verbanck,

Mathias Polfliet,

Daniël Schuermans,

Bart Ilsen,

Johan De Mey,

Eef Vanderhelst,

Jef Vandemeulebroucke

Publication year - 2020

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00105.2020

Subject(s) - supine position , lung , peripheral , washout , ventilation (architecture) , cardiology , medicine , physics , thermodynamics

A head-on comparison between imaging and multiple breath washout in supine smokers shows that computer tomography-measured unequal local lung expansion accounts for 50% or less of smoking-induced increase in ventilation heterogeneity. The contributions from unequal lung expansion and peripheral structure to the two main washout indices also explain their respective association with parametric response mapping indices.

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