Open AccessThe physiological effects of creatine supplementation in fetal sheep before, during, and after umbilical cord occlusion and global hypoxia
Author(s) -
Nhi T. Tran,
Anna Maria Muccini,
Rod J. Snow,
Ilias Nitsos,
Nadia Hale,
David Walker,
Stacey J. Ellery
Publication year - 2021
Publication title -
journal of applied physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.253
H-Index - 229
eISSN - 8750-7587
pISSN - 1522-1601
DOI - 10.1152/japplphysiol.00092.2021
Subject(s) - creatine , endocrinology , medicine , hypoxia (environmental) , fetus , umbilical cord , biology , chemistry , pregnancy , oxygen , anatomy , organic chemistry , genetics
Direct fetal creatine supplementation increased plasma and cerebral creatine concentrations but did not alter fetal body weight, basal cardiovascular output, or blood chemistry. Creatine-treated fetuses displayed changes to arterial oxygenation 24–72 h after acute global hypoxia. An increase in striatum total creatine levels following UCO was also noted and suggests that increasing creatine tissue availability may be an adaptive response against the effects of hypoxia.