English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Type 2 diabetes is characterized by reduced contractile force production and increased fatigability of skeletal muscle. While the maintenance of Ca 2+  homeostasis during muscle contraction is a requisite for optimal contractile function, the mechanisms underlying muscle contractile dysfunction in type 2 diabetes are unclear. Here, we investigated skeletal muscle contractile force and Ca 2+  flux during contraction and pharmacological stimulation in type 2 diabetic model mice ( db/db mice). Furthermore, we investigated the effect of treadmill exercise training on muscle contractile function. In male db/db mice, muscle contractile force and peak Ca 2+  levels were both lower during tetanic stimulation of the fast-twitch muscles, while Ca 2+  accumulation was higher after stimulation compared with control mice. While 6 wk of exercise training did not improve glucose tolerance, exercise did improve muscle contractile dysfunction, peak Ca 2+  levels, and Ca 2+  accumulation following stimulation in male db/db mice. These data suggest that dysfunctional Ca 2+  flux may contribute to skeletal muscle contractile dysfunction in type 2 diabetes and that exercise training may be a promising therapeutic approach for dysfunctional skeletal muscle contraction.    NEW &amp; NOTEWORTHY The purpose of this study was to examine muscle contractile function and Ca 2+  regulation as well as the effect of exercise training in skeletal muscle in obese diabetic mice ( db/db). We observed impairment of muscle contractile force and Ca 2+  regulation in a male type 2 diabetic animal model. These dysfunctions in muscle were improved by 6 wk of exercise training.

journal of applied physiology

Dysfunction of muscle contraction with impaired intracellular Ca<sup>2+</sup>handling in skeletal muscle and the effect of exercise training in male<i>db/db</i>mice

Dysfunction of muscle contraction with impaired intracellular Ca2+handling in skeletal muscle and the effect of exercise training in maledb/dbmice

Dysfunction of muscle contraction with impaired intracellular Ca²⁺handling in skeletal muscle and the effect of exercise training in maledb/dbmice