Modern approaches for investigating epigenetic signaling pathways | Zendy

Adam G. Evertts | Zendy; Barry M. Zee | Zendy; Benjamin A. García | Zendy

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Modern approaches for investigating epigenetic signaling pathways

Author(s) -

Adam G. Evertts,

Barry M. Zee,

Benjamin A. García

Publication year - 2010

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/japplphysiol.00007.2010

Subject(s) - epigenetics , dna methylation , histone , biology , epigenomics , computational biology , genetics , epigenesis , epigenetics of physical exercise , histone methylation , histone code , epigenetic regulation of neurogenesis , histone methyltransferase , dna , nucleosome , gene , gene expression

Epigenetics is increasingly being recognized as a central component of physiological processes as diverse as obesity and circadian rhythms. Primarily acting through DNA methylation and histone posttranslational modifications, epigenetic pathways enable both short- and long-term transcriptional activation and silencing, independently of the underlying genetic sequence. To more quantitatively study the molecular basis of epigenetic regulation in physiological processes, the present review informs the latest techniques to identify and compare novel DNA methylation marks and combinatorial histone modifications across different experimental conditions, and to localize both DNA methylation and histone modifications over specific genomic regions.

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