Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain | Zendy

Jonathan Day | Zendy; Ami Frank | Zendy; James P. O’Callaghan | Zendy; Barbara W. DeHart | Zendy

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Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain

Author(s) -

Jonathan Day,

Ami Frank,

James P. O’Callaghan,

Barbara W. DeHart

Publication year - 1998

Publication title -

journal of applied physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.253

H-Index - 229

eISSN - 8750-7587

pISSN - 1522-1601

DOI - 10.1152/jappl.1998.85.2.716

Subject(s) - glial fibrillary acidic protein , spaceflight , corticosterone , hippocampal formation , endocrinology , medicine , messenger rna , biology , chemistry , immunohistochemistry , biochemistry , hormone , gene , engineering , aerospace engineering

This study evaluated effects of bone morphogenetic protein II (BMP) on glial fibrillary acidic protein (GFAP) in the brain of female Fischer 344 rats during 14 days of spaceflight. GFAP mRNA decreased in vehicle-implanted rats flown on the space shuttle by 53 and 48% in the stratum moleculare and stratum lacunosum moleculare hippocampal subregions, respectively. GFAP mRNA was not significantly affected by BMP implantation during spaceflight. Rats returning from space exhibited a 56% increase in serum corticosterone. BMP treatment did not additively increase corticosterone elevations in microgravity but appeared to increase serum corticosterone and reduce GFAP mRNA in the stratum moleculare in control rats. These data suggest that exposure to microgravity reduces GFAP expression in hippocampal astrocytes.

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