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Responses of cerebellar respiratory-related neurons (CRRNs) within the rostral fastigial nucleus and the phrenic neurogram to activation of respiratory mechano- and chemoreceptors were recorded in anesthetized, paralyzed, and ventilated cats. Respiratory challenges included the following: 1 ) cessation of the ventilator for a single breath at the end of inspiration (lung inflation) or at functional residual capacity, 2) cessation of the ventilator for multiple breaths, and 3) exposure to hypercapnia. Nineteen CRRNs having spontaneous activity during control conditions were characterized as either independent (basic, n = 14) or dependent (pump, n = 5) on the ventilator movement. Thirteen recruited CRRNs showed no respiratory-related activity until breathing was stressed. Burst durations of expiratory CRRNs were prolonged by sustained lung inflation but were inhibited when the volume was sustained at functional residual capacity; it was vice versa for inspiratory CRRNs. Multiple-breath cessation of the ventilator and hypercapnia significantly increased the firing rate and/or burst duration concomitant with changes noted in the phrenic neurogram. We conclude that CRRNs respond to respiratory inputs from CO2 chemo- and pulmonary mechanoreceptors in the absence of skeletal muscle contraction.

Respiratory-related neurons of the fastigial nucleus in response to chemical and mechanical challenges