Fibrin turnover and pleural organization: bench to bedside | Zendy

Andrey A. Komissarov | Zendy; Najib M. Rahman | Zendy; Gary Lee | Zendy; Galina Florova | Zendy; Sreerama Shetty | Zendy; Richard Idell | Zendy; Mitsuo Ikebe | Zendy; Kumuda C. Das | Zendy; Torry A. Tucker | Zendy; Steven Idell | Zendy

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Fibrin turnover and pleural organization: bench to bedside

Author(s) -

Andrey A. Komissarov,

Najib M. Rahman,

Gary Lee,

Galina Florova,

Sreerama Shetty,

Richard Idell,

Mitsuo Ikebe,

Kumuda C. Das,

Torry A. Tucker,

Steven Idell

Publication year - 2018

Publication title -

ajp lung cellular and molecular physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.892

H-Index - 163

eISSN - 1522-1504

pISSN - 1040-0605

DOI - 10.1152/ajplung.00501.2017

Subject(s) - medicine , tissue plasminogen activator , plasminogen activator , intensive care medicine , bench to bedside , fibrinolytic agent , fibrin , activator (genetics) , fibrinolysis , mesothelial cell , bioinformatics , pathology , immunology , biology , medical physics , receptor

Recent studies have shed new light on the role of the fibrinolytic system in the pathogenesis of pleural organization, including the mechanisms by which the system regulates mesenchymal transition of mesothelial cells and how that process affects outcomes of pleural injury. The key contribution of plasminogen activator inhibitor-1 to the outcomes of pleural injury is now better understood as is its role in the regulation of intrapleural fibrinolytic therapy. In addition, the mechanisms by which fibrinolysins are processed after intrapleural administration have now been elucidated, informing new candidate diagnostics and therapeutics for pleural loculation and failed drainage. The emergence of new potential interventional targets offers the potential for the development of new and more effective therapeutic candidates.

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