Regulation of pulmonary endothelial barrier function by kinases | Zendy

Nektarios Barabutis | Zendy; Alexander D. Verin | Zendy; John D. Catravas | Zendy

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Regulation of pulmonary endothelial barrier function by kinases

Author(s) -

Nektarios Barabutis,

Alexander D. Verin,

John D. Catravas

Publication year - 2016

Publication title -

ajp lung cellular and molecular physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.892

H-Index - 163

eISSN - 1522-1504

pISSN - 1040-0605

DOI - 10.1152/ajplung.00233.2016

Subject(s) - barrier function , endothelium , kinase , microbiology and biotechnology , phosphorylation , function (biology) , vascular permeability , endothelial stem cell , lung , biology , chemistry , medicine , biochemistry , endocrinology , in vitro

The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

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