Chloride in airway smooth muscle: the ignored anion no longer? | Zendy

George Gallos | Zendy; Peter D. Yim | Zendy; Charles W. Emala | Zendy

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Chloride in airway smooth muscle: the ignored anion no longer?

Author(s) -

George Gallos,

Peter D. Yim,

Charles W. Emala

Publication year - 2012

Publication title -

ajp lung cellular and molecular physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.892

H-Index - 163

eISSN - 1522-1504

pISSN - 1040-0605

DOI - 10.1152/ajplung.00053.2012

Subject(s) - chloride channel , airway , contractility , chloride , calcium , smooth muscle , chemistry , neuroscience , biophysics , biology , medicine , anesthesia , organic chemistry

This Perspectives accompanies an Editorial Focus that summarizes new developments concerning the role of chloride in airway smooth muscle physiology. We provide several observations and mechanistic insights to reconcile recent experimental evidence with existing paradigms concerning chloride channel-mediated effects on airway smooth muscle tone. In addition, we highlight the potentially complex and dynamic nature that chloride currents and membrane potential have on calcium handling and airway smooth muscle contractility.

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