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it is well known that smooth muscle contraction, whether spontaneous or following pharmacological stimulation, occurs in two phases: the initial phasic followed by the tonic phase ([1][1], [2][2], [5][3], [6][4], [11][5], [12][6], [14][7], [16][8], [17][9], [22][10], [23][11], [25][12], [33][13], [

Ca2+/calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains, the internal anal sphincter smooth muscle tone

Ca²⁺/calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains, the internal anal sphincter smooth muscle tone